Research article2021Peer reviewedOpen access
Enhanced detection of ATTR amyloid using a nanofibril-based assay
Rahman, M. Mahafuzur; Schmuck, Benjamin; Hansson, Henrik et al.
Torleif Härd
Department of Molecular Sciences
Faculty of Natural Resources and Agricultural Sciences
Email: Torleif.Hard@slu.se
Publications
2021
2019
Research article2019Peer reviewedOpen access
Coupled chemistry kinetics demonstrate the utility of functionalized Sup35 amyloid nanofibrils in biocatalytic cascades
Schmuck, Benjamin; Gudmundsson, Mikael; Härd, Torleif et al.
Research article2019Peer reviewedOpen access
Affibody-Mediated Sequestration of Amyloid beta Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model
Boutajangout, Allal; Lindberg, Hanna; Awwad, Abdulaziz et al.
2018
Research article2018Peer reviewedOpen access
The kinetics of TEM1 antibiotic degrading enzymes that are displayed on Ure2 protein nanofibrils in a flow reactor
Schmuck, Benjamin; Sandgren, Mats; Hard, Torleif.
Research article2018Peer reviewedOpen access
Protofibrillar and Fibrillar Amyloid-beta Binding Proteins in Cerebrospinal Fluid
Rahman, M. Mahafuzur; Westermark, Gunilla T.; Zetterberg, Henrik et al.
Research article2018Peer reviewed
Production of Ready-To-Use Functionalized Sup35 Nanofibrils Secreted by Komagataella pastoris
Schmuck, Benjamin; Gudmundsson, Mikael; Blomqvist, Johanna et al.
2017
Research article2017Peer reviewedOpen access
Identification of proteins that specifically recognize and bind protofibrillar aggregates of amyloid-β
Wahlberg, Elisabet; Rahman, M. Mahafuzur; Lindberg, Hanna et al.
Research article2017Peer reviewed
A fine-tuned composition of protein nanofibrils yields an upgraded functionality of displayed antibody binding domains
Schmuck, Benjamin; Sandgren, Mats; Hard, Torleif.
2016
Research article2016Peer reviewed
Combined Solution- and Magic Angle Spinning NMR Reveals Regions of Distinct Dynamics in Amyloid beta Protofibrils
Lendel, Christofer; Sparrman, Tobias; Mayzel, Maxim et al.
Research article2016Peer reviewedOpen access
Structural basis for Myf and Psa fimbriae-mediated tropism of pathogenic strains of Yersinia for host tissues
Pakharukova, Natalia; Roy, Saumendra Prasad; Härd, Torleif et al.
2015
Conference abstract2015Peer reviewed
Solid-state NMR and molecular modeling provide structural information on amyloid-beta protofibrils
Härd, T..
Conference abstract2015Peer reviewed
Engineered binding proteins to amyloidogenic intrinsically disordered proteins
Shaykhalishahi, Hamed; Mirecka, Ewa; Gauhar, Aziz et al.
Research article2015Peer reviewed
Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation
Shaykhalishahi, Hamed; Gauhar, Aziz; Wördehoff, Michael M. et al.
Research article2015Peer reviewedOpen access
A truncated and dimeric format of an Affibody library on bacteria enables FACS-mediated isolation of amyloid-beta aggregation inhibitors with subnanomolar affinity
Lindberg, Hanna; Härd, Torleif; Löfblom, John et al.
Research article2015Peer reviewed
Binding of Human Proteins to Amyloid-beta Protofibrils
Rahman, Mahafuzur; Zetterberg, Henrik; Lendel, Christofer et al.
Research article2015Peer reviewed
A beta-Hairpin-Binding Protein for Three Different Disease-Related Amyloidogenic Proteins
Shaykhalishahi, Hamed; Mirecka, Ewa A.; Gauhar, Aziz et al.
2014
Research article2014Peer reviewed
A Hexameric Peptide Barrel as Building Block of Amyloid-beta Protofibrils
Lendel, Christofer; Bjerring, Morten; Dubnovitsky, Anatoly et al.
Research article2014Peer reviewed
Amyloid Fibrils: Formation, Polymorphism, and Inhibition
Härd, Torleif.
2013
Research article2013Peer reviewedOpen access
Amyloid-beta Protofibrils: Size, Morphology and Synaptotoxicity of an Engineered Mimic
Dubnovitsky, Anatoly; Sandberg, Anders; Rahman, Mahafuzur et al.
Research article2013Peer reviewedOpen access
High-affinity binding to staphylococcal protein A by an engineered dimeric Affibody molecule
Lindborg, Malin; Dubnovitsky, Anatoly; Olesen, Kenneth et al.
Book chapter2013Peer reviewed
Self-Cleaving Mucins
Härd, Torleif.
Research article2013Peer reviewed
Staphylococcal display for combinatorial protein engineering of a head-to-tail affibody dimer binding the Alzheimer amyloid-ss peptide
Lindberg, Hanna; Johansson, Anna; Härd, Torleif et al.
2012
Research article2012Peer reviewed
Folding-Reaction Coupling in a Self-Cleaving Protein
Wallin, Goran; Hard, Torleif; Aqvist, Johan.
Research article2012Peer reviewed
Inhibition of Amyloid Formation
Härd, Torleif; Lendel, Christofer.
2011
Review article2011Peer reviewedOpen access
Protein engineering to stabilize soluble amyloid beta-protein aggregates for structural and functional studies
Härd, Torleif.
Research article2011Peer reviewedOpen access
Monte Carlo Study of the Formation and Conformational Properties of Dimers of A beta 42 Variants
Mitternacht, Simon; Staneva, Iskra; Härd, Torleif et al.
2010
Research article2010Peer reviewed
Conserved Hydrophobic Clusters on the Surface of the Caf1A Usher C-Terminal Domain Are Important for F1 Antigen Assembly
Dubnovitsky, Anatoly; Duck, Zoe; Härd, Torleif et al.
Research article2010Peer reviewedOpen access
Structural basis for high-affinity HER2 receptor binding by an engineered protein
Eigenbrot, Charles; Ultsch, Mark; Dubnovitsky, Anatoly et al.
Research article2010Peer reviewedOpen access
Sequestration of the A beta Peptide Prevents Toxicity and Promotes Degradation In Vivo
Luheshi, Leila; Hoyer, Wolfgang; Pereira de Barros, Teresa et al.
Research article2010Peer reviewed
Comparing the folding free-energy landscapes of A beta 42 variants with different aggregation properties
Mitternacht, Simon; Staneva, Iskra; Härd, Torleif et al.
Research article2010Peer reviewedOpen access
Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering
Sandberg Anders, Luheshi Leila, Söllvander Sofia, Pereira de Barros Teresa, Macao Bertil, Knowles Tuomas, Biverstål Henrik, Lendel Christofer, Ekholm-Petterson Frida, Dubnovitsky Anatoly, Lannfelt Lars, Dobson Christopher, Härd Torleif.
2009
Patent2009
Stable amyloid beta monomers and oligomers
Härd, Torleif; Sandberg, Anders.
Research article2009Peer reviewed
Protein Autoproteolysis: Conformational Strain Linked to the Rate of Peptide Cleavage by the pH Dependence of the N -> O Acyl Shift Reaction
Johansson, Denny G. A.; Wallin, Goran; Sandberg, Anders et al.
1998
Research article1998Peer reviewed
Architecture of nonspecific protein-DNA interactions in the Sso7d-DNA complex
Agback, P; Baumann, H; Knapp, S et al.
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